Descripción: Omics approaches, particularly proteomics, are powerful tools for generating hypotheses that can be functionally tested and verified. Given the complexity of neurodegenerative disease pathogenesis, integrative strategies are essential. I will illustrate this through three case studies: the dysfunction of the mitochondrial protease PITRM1 in spinocerebellar ataxia and Alzheimer’s disease, the contribution of senescent microglia to Alzheimer’s pathology, and the disruption of Rab protein-mediated vesicular trafficking in Parkinson’s disease. By coupling omics data with systems biology, I aim to demonstrate how these approaches can uncover mechanistic insights and guide meaningful functional validation.
Ponente: Tiziana Alberio, PhD
Associate Professor of Biochemistry
Department of Science and high Technology
Laboratory of Biochemistry and functional Proteomics
University of Insubria, Italy
BIOSKETCH
Tiziana Alberio, born in Busto Arsizio, Italy, on May 3, 1981, obtained her PhD in Neurobiology in 2010.
She is currently Associate Professor of Biochemistry at the University of Insubria, Dept. of Science and High Technology, Como, Italy. She teaches Cellular Biochemistry and Proteomics in the M.Sc.
Biomedical Sciences and Biochemistry and Biochemical methods in the M.Sc. of environmental Science.
She is the tutor of several M.Sc. students and PhD students.
Her research focuses on pathogenic mechanisms of neurodegeneration, in particular of Parkinson’s Disease (PD), and of Amyotrophic lateral sclerosis and Alzheimer Disease in recent years. She uses a multidisciplinary approach (with a combination of biochemistry, proteomics, systems biology) for the study of (i) the role of mitochondrial impairment in neurodegeneration, (ii) the study of specific and common pathways of neurodegeneration; (iii) the molecular mechanisms involved in PD pathogenesis iv) the role of protein networks in revealing new therapeutic targets for fibromyalgia. She published more than 40 indexed (Scopus/ISI) publications (H index, 21; citations, 1162). She acts as frequent reviewer for scientific journals and she is member of the editorial board of BMC Genomics (section Proteomics).
Since 2019 she has been in the Italian Proteomics Association (ItPA) EC, in the first mandate as the responsible for education activities, and then as the treasurer. She is a member of the Education Committee of the European Proteomics Association. She is in the Board of the PhD school “Experimental and translational medicine”. She is in the Scientific Board of the Centre of Healthy Aging (CRIS) and of Center for Research in Neuroscience (University of Insubria). She was in the Organization and Scientific Board of several national and international scientific meetings.